- 100% of the 35 studies to date report positive effects. Early treatment is more successful, with an estimated reduction of 84% in the effect measured using a random effects meta-analysis, RR 0.16 [0.08-0.33]. Prophylactic use also shows high effectiveness.
- 100% of the 17 Randomized Controlled Trials (RCTs) report positive effects, with an estimated reduction of 71%, RR 0.29 [0.17-0.51].
- The probability that an ineffective treatment generated results as positive as the 35 studies to date is estimated to be 1 in 34 billion (p= 0.000000000029).
