That’s the hope of dozens of research groups and companies working on new kinds of inoculation. Rather than relying on injections, these use sprays or drops administered through the nose or mouth that aim to improve protection against the virus SARS-CoV-2.
This week, an inhaled version of a COVID-19 vaccine, produced by the Chinese company CanSino Biologics in Tianjin, was approved for use as a booster dose in China.
It’s one of more than 100 oral or nasal vaccines in development around the world. In theory, these vaccines could prime immune cells in the thin mucous membranes that line cavities in the nose and mouth where SARS-CoV-2 enters the body, and quickly stop the virus in its tracks — before it spreads. Vaccine developers hope that these ‘mucosal’ vaccines will prevent even mild cases of illness and block transmission to other people, achieving what’s known as sterilizing immunity. A few mucosal vaccines are already approved for other diseases, including a sprayable vaccine against influenza.
Evidence in animals supports the idea that sterilizing immunity can be induced against COVID-19, although data from humans are scant. Nature explains why mucosal vaccines might help to quash SARS-CoV-2, and what the latest findings mean.
La Asociación Civil Academia de Ciencias Médicas de la Provincia de Santa Fe, con personería jurídica aprobada por la Inspección General de Personas Jurídicas de la provincia el día 2 de marzo de 2017, constituye la Academia de Ciencias Médicas de Santa Fe, tal como lo indican sus estatutos. Leer más